“Are psychedelics good for you? It’s such a hippie relic of a question that it’s almost embarrassing to ask. But a quiet psychedelic renaissance is beginning at the highest levels of American science, including the National Institute of Mental Health (NIMH) and Harvard, which is conducting what is thought to be its first research into therapeutic uses of psychedelics (in this case, Ecstasy) since the university fired Timothy Leary in 1963.”

“Last year two top journals, the Archives of General Psychiatry and the Journal of Clinical Psychiatry, published papers showing clear benefits from the use of psychedelics to treat mental illness. Both were small studies, just 27 subjects total. But the Archives paper–whose lead author, Dr. Carlos Zarate Jr., is chief of the Mood and Anxiety Disorders Research Unit at NIMH–found “robust and rapid antidepressant effects” that remained for a week after depressed subjects were given ketamine (colloquial name: Special K or usually just k). In the other study, a team led by Dr. Francisco Moreno of the University of Arizona gave psilocybin (the merrymaking chemical in psychedelic mushrooms) to obsessive-compulsive-disorder patients, most of whom later showed “acute reductions in core OCD symptoms.” Now researchers at Harvard are studying how Ecstasy might help alleviate anxiety disorders, and the Beckley Foundation, a British trust, has received approval to begin what will be the first human studies with LSD since the 1970s.”

“…a Leary for a less naive age: Richard Doblin. Also a Harvard guy–his Ph.D. is in public policy–Doblin founded the Multidisciplinary Association for Psychedelic Studies (MAPS) in 1986 to help scientists get funding and approval to study the drugs. (Doblin, 53, says he was too shy for the ’60s, but he was inspired by the work of psychologist Stanislav Grof, who authored a 1975 book about promising LSD research–research that ended with antidrug crackdowns.) Doblin has painstakingly worked with intensely skeptical federal authorities to win necessary permissions. MAPS helped launch all four of the current Ecstasy studies, a process that took two decades. It’s the antithesis of Leary’s approach.”

If you have ever written about using psychedelics, you may be denied entry (or rentry?) into the United States

“Andrew Feldmar, a well-known Vancouver psychotherapist, rolled up to the Blaine border crossing last summer as he had hundreds of times in his career. At 66, his gray hair, neat beard, and rimless glasses give him the look of a seasoned intellectual. He handed his passport to the U.S. border guard and relaxed, thinking he would soon be with an old friend in Seattle. The border guard turned to his computer and googled “Andrew Feldmar.”

The psychotherapist’s world was about to turn upside down.

The Blaine border guard explained that Feldmar had been pulled out of the line as part of a random search. He seemed friendly, even as he took away Feldmar’s passport and car keys. While the contents of his car were being searched, Feldmar and the officer talked. He asked Feldmar what profession he was in.

When Feldmar said he was psychologist, the official typed his name into his Internet search engine. Before long the customs guard was engrossed in an article Feldmar had published in the spring 2001 issue of the journal Janus Head. The article concerned an acid trip Feldmar had taken in London, Ontario, and another in London, England, almost forty years ago. It also alluded to the fact that he had used hallucinogenics as a “path” to understanding self and that in certain cases, he reflected, it could “be preferable to psychiatry.” Everything seemed to collapse around him, as a quiet day crossing the border began to turn into a nightmare.”

Ecstasy really does unleash the love hormone

“Clubbers who take the “love drug” ecstasy really might be “loved up”. Studies in rats suggest the drug causes a brain surge of oxytocin – the hormone that helps bond couples, as well as mothers to their babies.

Earlier research found increased oxytocin in the blood of people who had taken ecstasy. However, many drugs increase blood oxytocin without raising it in the brain – something thought necessary for any “pro-social” effects.

Iain McGregor at the University of Sydney in Australia, and his colleagues studied the effects of ecstasy in rats, which, like people, become more sociable on the drug. “It’s very characteristic behaviour. They lie next to each other and chill out,” McGregor says.

The team gave the rats the equivalent of two to three ecstasy tablets in an adult human and found that the drug activated oxytocin-containing neurons in an area of their brains called the hypothalamus. When they gave the rats a drug that blocked brain receptors for oxytocin, the increased sociability almost disappeared.

Why it didn’t disappear entirely isn’t clear. It could be that the dose of the receptor blocker was too low, or that other brain chemicals, such as dopamine, are also involved in triggering the sociable behaviour, McGregor says.”